Dose Calculator
Calculate precise medication doses
Understanding the Medications
Research has established clear differences between these medications: Tirzepatide functions as a dual GIP/GLP-1 receptor agonist, while Semaglutide targets only GLP-1 receptors. This fundamental difference in mechanism of action explains why the transition between medications requires careful consideration.
Medication Comparison
Tirzepatide
- Dual GIP/GLP-1 agonist
- 2.5-15mg weekly
- Peak effect: 10-12 hours
- Half-life: ~5 days
- Generally milder GI effects
Semaglutide
- GLP-1 agonist only
- 0.25-2.4mg weekly
- Peak effect: 24-48 hours
- Half-life: ~7 days
- Moderate GI effects
Transition Protocol
Step 1
Complete current Tirzepatide cycle
Step 2
7-day washout period
Step 3
Start Semaglutide at appropriate dose
Step 4
Monitor response closely
Starting Dose Guidelines
| Current Tirzepatide Dose | Starting Semaglutide Dose |
|---|---|
| 5mg Tirzepatide | 0.5mg Semaglutide |
| 10mg Tirzepatide | 1.0mg Semaglutide |
| 15mg Tirzepatide | 1.7mg Semaglutide |
Important Safety Information
The transition between medications should always be supervised by healthcare providers. Individual responses may vary, and dose adjustments may be needed based on your specific situation.
Note: This article presents research analysis only. Always consult healthcare providers about medication transitions and treatment decisions.
Free Tools to Help Your Transition
Shotz App
Our free medication tracking app helps you manage your transition smoothly:
- Record your last Tirzepatide dose
- Track the washout period
- Monitor medication levels
- Track your response to the new medication
- View your medication history
Dose Converter
Our free calculator helps you convert doses accurately:
- Convert Tirzepatide to Semaglutide doses
- Calculate appropriate starting doses
- Track dose adjustments
- Save your calculations
Understanding the Switch
When transitioning between Tirzepatide and Semaglutide, it's important to understand the differences in their mechanisms of action and dosing requirements. Use our dose calculator to help determine appropriate starting doses, and track your medication schedule with Shotz to ensure proper timing of your doses.