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Understanding the Medications
Research has established clear differences between these medications: Tirzepatide functions as a dual GIP/GLP-1 receptor agonist, while Semaglutide targets only GLP-1 receptors. This fundamental difference in mechanism of action explains why the transition between medications requires careful consideration.
Medication Comparison
Tirzepatide
- Dual GIP/GLP-1 agonist
- 2.5-15mg weekly
- Peak effect: 10-12 hours
- Half-life: ~5 days
- Generally milder GI effects
Semaglutide
- GLP-1 agonist only
- 0.25-2.4mg weekly
- Peak effect: 24-48 hours
- Half-life: ~7 days
- Moderate GI effects
Transition Protocol
Step 1
Complete current Tirzepatide cycle
Step 2
7-day washout period
Step 3
Start Semaglutide at appropriate dose
Step 4
Monitor response closely
Starting Dose Guidelines
| Current Tirzepatide Dose | Starting Semaglutide Dose |
|---|---|
| 5mg Tirzepatide | 0.5mg Semaglutide |
| 10mg Tirzepatide | 1.0mg Semaglutide |
| 15mg Tirzepatide | 1.7mg Semaglutide |
Important Safety Information
The transition between medications should always be supervised by healthcare providers. Individual responses may vary, and dose adjustments may be needed based on your specific situation.
Note: This article presents research analysis only. Always consult healthcare providers about medication transitions and treatment decisions.